All medications

Biologics

Guselkumab

Brand names: Tremfya

An IL-23 inhibitor for psoriatic arthritis, psoriasis and bowel disease.

Video lesson

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Guselkumab
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Animated explainer

Immune cellTarget cellIL-23Medicine
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How it works · Blocking IL-23
Immune cells release IL-23

IL-23 is a chemical messenger. Overactive immune cells release it to call in more inflammation.

What it’s used for

Psoriatic arthritis, psoriasis, ulcerative colitis and Crohn’s disease.

How it works

It blocks IL-23, which sustains the immune cells behind psoriatic inflammation.

How it’s taken

An injection under the skin every 4 or 8 weeks after starting doses.

Side effects

Colds, headache, injection-site reactions and mild liver enzyme rises.

Monitoring

TB screening and liver tests.

Good to know

Very convenient dosing and a favorable safety record.

← Ustekinumab

Risankizumab →

At a glance

Class

Biologics

Brand names

Tremfya

Reviewed by Farhan Tahir, MD, FACR

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