All medications
Targeted oral therapies
Avacopan
Brand names: Tavneos
An oral medicine that blocks a complement signal driving ANCA vasculitis, helping lower steroid use.
Video lesson
Animated explainer
What it’s used for
Severe active ANCA-associated vasculitis (GPA and MPA), together with standard therapy.
How it works
It blocks the C5a receptor on neutrophils, so these cells are less activated and attracted into vessel walls.
How it’s taken
Capsules twice a day with food.
Side effects
Nausea, headache, high blood pressure and liver enzyme rises. Rarely, serious liver injury.
Monitoring
Liver tests before and during treatment, and hepatitis B screening.
Good to know
Check interactions with other medicines, especially some antifungals and antibiotics.
At a glance
Class
Targeted oral therapies
Brand names
Tavneos
Reviewed by Farhan Tahir, MD, FACR
Questions about your own care?
Book an in-person or telehealth consultation with Dr. Tahir.
For education only. Don’t start, stop or change a medicine without talking to your care team.