All medications
Biologics
Anifrolumab
Brand names: Saphnelo
A biologic for lupus that blocks the type I interferon receptor.
Video lesson
Animated explainer
What it’s used for
Moderate to severe systemic lupus, added to standard therapy.
How it works
Many people with lupus have too much type I interferon signaling. Anifrolumab blocks its receptor.
How it’s taken
An IV infusion every 4 weeks.
Side effects
Upper respiratory infections, bronchitis, infusion reactions and shingles.
Monitoring
Standard lupus labs. Consider the shingles vaccine beforehand.
Good to know
Often helpful for lupus skin and joint disease.
At a glance
Class
Biologics
Brand names
Saphnelo
Reviewed by Farhan Tahir, MD, FACR
Questions about your own care?
Book an in-person or telehealth consultation with Dr. Tahir.
For education only. Don’t start, stop or change a medicine without talking to your care team.