All conditions
Vasculitis & polymyalgia
Microscopic Polyangiitis
Also known as: MPA
A small-vessel ANCA-associated vasculitis that most often affects the kidneys and lungs.
Video lesson
Animated explainer
What it is
MPA inflames small blood vessels without forming granulomas. Kidney inflammation (glomerulonephritis) is very common and can progress quickly, and lung bleeding or scarring can occur.
Symptoms
Fatigue, fever, weight loss, joint and muscle aches, rash, numbness or weakness in the hands or feet, cough or shortness of breath, and blood or protein in the urine.
How it’s diagnosed
MPO-ANCA is usually positive. Urine tests, kidney function, chest imaging and kidney biopsy confirm the diagnosis and its severity.
Treatment
Rituximab or cyclophosphamide with steroids induces remission, and avacopan can lower steroid exposure. Maintenance therapy reduces relapse risk.
Living with it
Keep up regular lab checks even when you feel well. Protect your kidneys by controlling blood pressure and avoiding NSAIDs unless your doctor approves.
At a glance
Category
Vasculitis & polymyalgia
Also known as
MPA
Reviewed by Farhan Tahir, MD, FACR
Questions about your own care?
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